Youngbin Lee | Bioelectronics at MIT

A multifunctional tool for cognitive neuroscience

Thu, 19 Oct 2023 00:00:00 +0000

A team of researchers at MIT’s McGovern and Picower Institutes has advanced the clinical potential of a thin, flexible fiber designed to simultaneously monitor and manipulate neural activity at targeted sites in the brain. The collaborative team improved upon an earlier model of the multifunctional fiber, developed in the lab of McGovern Institute Associate Investigator Polina Anikeeva, to explore dynamic changes to neural signaling as large animals engage in a working memory task. The results appear Oct. 6 in Science Advances.

The new device, developed by Indie Garwood, who recently received her PhD in the Harvard-MIT Program in Health Sciences and Technology, includes four microelectrodes for detecting neural activity and two microfluidic channels through which drugs can be delivered. This means scientists can deliver a drug that alters neural signaling within a particular part of the brain, then monitor the consequences for local brain activity. This technology was a collaborative effort between Anikeeva, who is also the Matoula S. Salapatas Professor in Materials Science and Engineering and a professor of brain and cognitive sciences, and Picower Institute Investigators Emery Brown and Earl Miller, who jointly supervised Garwood to develop a multifunctional neurotechnology for larger and translational animal models, which are necessary to investigate the neural circuits that underlie high-level cognitive functions. With further development and testing, similar devices might one day be deployed to diagnose or treat brain disorders in human patients.

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Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

Fri, 06 Oct 2023 00:00:00 +0000

Magnetic robots walk, crawl, and swim

Fri, 07 Jul 2023 00:00:00 +0000

MIT scientists have developed tiny, soft-bodied robots that can be controlled with a weak magnet. The robots, formed from rubbery magnetic spirals, can be programmed to walk, crawl, swim — all in response to a simple, easy-to-apply magnetic field.

“This is the first time this has been done, to be able to control three-dimensional locomotion of robots with a one-dimensional magnetic field,” says Professor Polina Anikeeva, whose team published an open-access paper on the magnetic robots June 3 in the journal Advanced Materials. “And because they are predominantly composed of polymer and polymers are soft, you don’t need a very large magnetic field to activate them. It’s actually a really tiny magnetic field that drives these robots,” adds Anikeeva, who is a professor of materials science and engineering and brain and cognitive sciences at MIT, a McGovern Institute for Brain Research associate investigator, as well as the associate director of MIT’s Research Laboratory of Electronics and director of MIT’s K. Lisa Yang Brain-Body Center.

The new robots are well suited to transport cargo through confined spaces and their rubber bodies are gentle on fragile environments, opening the possibility that the technology could be developed for biomedical applications. Anikeeva and her team have made their robots millimeters long, but she says the same approach could be used to produce much smaller robots.

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Magnetically Actuated Fiber‐Based Soft Robots

Sat, 03 Jun 2023 00:00:00 +0000

Selectively Micro-Patternable Fibers via In-Fiber Photolithography

Wed, 25 Nov 2020 00:00:00 +0000