Electrochemical Modulation of Carbon Monoxide-Mediated Cell Signaling

Thu, 15 Jul 2021 00:00:00 +0000

Gaseous Messenger Molecule

Mon, 06 Jul 2020 00:00:00 +0000

Nitric oxide is an important signaling molecule in the body, with a role in building nervous system connections that contribute to learning and memory. It also functions as a messenger in the cardiovascular and immune systems.

But it has been difficult for researchers to study exactly what its role is in these systems and how it functions. Because it is a gas, there has been no practical way to direct it to specific individual cells in order to observe its effects. Now, a team of scientists and engineers at MIT and elsewhere has found a way of generating the gas at precisely targeted locations inside the body, potentially opening new lines of research on this essential molecule’s effects.

The findings are reported today in the journal Nature Nanotechnology, in a paper by MIT professors Polina Anikeeva, Karthish Manthiram, and Yoel Fink; graduate student Jimin Park; postdoc Kyoungsuk Jin; and 10 others at MIT and in Taiwan, Japan, and Israel.

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In situ electrochemical generation of nitric oxide for neuronal modulation

Mon, 29 Jun 2020 00:00:00 +0000

Karthish Manthiram | Bioelectronics at MIT

Electrochemical Modulation of Carbon Monoxide-Mediated Cell Signaling

Gaseous Messenger Molecule

In situ electrochemical generation of nitric oxide for neuronal modulation